San Salvatore is located in the heart of the Cilento National Park, near Paestum, Stio and Giungano, in the Campania region of southern Italy. With 149 hectares devoted to organically-farmed agriculture, including vineyards, olive groves, and crops that support their 550-head herd of water buffalo, San Salvatore has quickly become one of Italy's most environmentally-conscious azienda agricolas. In 2006 Giuseppe Pagano created San Salvatore 1988 from a series of unique plots of land in Cilento and various vineyards across the region. The winery is named for Giuseppe's firstborn son, Salvatore, who was born in 1988.

San Salvatore's first harvest was in 2009, but their historic vineyards were planted by the Ancient Greeks with the same varieties that continue to flourish in this region today: Falanghina, Fiano, Greco, and Aglianico. This mountainous region of Campania has a high level of biodiversity and the soil is rich in minerals. The influence of the nearby sea and ideal sun exposure help to create an ideal microclimate for viticulture and other crops.

Deeply committed to preserving the delicate balance of the land, San Salvatore takes a special interest in cultivating the vineyards without synthetic products or genetically modified organisms and uses biodynamic preparations that favor the natural fertility of the ground. Vines are also protected from pests and disease with the careful use of copper and sulfur when necessary. San Salvatore has truly excelled at achieving sustainable living ideals and continues to set the standard for environmental practices in the Italian wine industry.