The domaine was established by Henri Prudhon who was born and raised as a vigneron in the village of Saint Aubin since his birth in 1921. He and his wife, Marguerite, combined forces upon their marriage in 1945, putting their small vineyard holdings together to form the Domaine Henri Prudhon. Their son, Gerard, born in 1949, joined the family enterprise and it was Gerard who decided, in the early years of the 1980s, to begin bottling the wines of the estate rather than selling off the fruits of their labors to the local negociants. Gerard's two sons, Vincent and Philippe, have now taken over the direction of the domaine, working under the watchful eye of Gerard.

The domain encompasses 14.5 hectares of vineyards and produces on the order of 7,500 cases of wine annually, eighty-five percent of which is exported outside of France. The vineyards are managed with the objective of intervening as little as possible in the natural vegetative cycle. The vines are planted to a density of 10,000 per hectare. The harvest is manual and the objective of the domaine is to collect grapes when they achieve a balance between sugar and acidity.

At harvest, the white grapes are pressed in a pneumatic pressoir and then are racked into barrel to undergo both fermentations: alcoholic and malolactic. The reds are destemmed and experience a cold maceration of just a day or two; then, the alcoholic fermentation proceeds for an additional ten to twelve days. Very little new oak is used when aging the red wines.